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Quantitative nuclear magnetic resonance (Q-NMR) measurements are especially useful for analysis of complex samples where high specificity is needed or when a pure standard of the analyte is not available. Often the sample can be analyzed with a minimum of preparation. Q-NMR has utility in various areas including:

  • Purity analysis
  • Food and wine quality analysis
  • Impurity analysis
  • Process monitoring
  • Quality and degradation of pharmaceuticals
  • Determination of enantiomeric excess

This module provides a brief overview of basic NMR theory, a tutorial discussing the practical aspects of Q-NMR, a virtual experiment utilizing an NMR simulator, an exercise that makes use of real NMR data you can download and analyze, and a Q-NMR lab experiment on the determination of malic acid in fruit juice. Several Q-NMR applications are highlighted and links to additional resources are provided. Also provided is a set of questions designed for use as in-class group learning activities, along with a guide for instructors that contains both the questions and the answers.

The goals of this module are to provide students with sufficient background and training that they are prepared to perform accurate quantitative NMR measurements. The module includes a brief introduction to the basic theory of NMR and relates that theory to the practical aspects of quantitative NMR measurements. Students can reinforce their theoretical knowledge by performing exercises in the Virtual Laboratory, making use of an NMR simulation program, and through a quantitative NMR laboratory experiment determining the amount of malic and citric acids in fruit juice. The module includes several short descriptions of real-world applications of quantitative NMR and points interested students toward additional resources for learning more about NMR spectroscopy.

Table of Contents

Developed by:
Dr. Albert Korir
Drury University

Dr. Cynthia K. Larive
University of California – Riverside